Abstract (hsc full form)
Abstract ( hsc full form ) It is the mammalian blood System is comprised of more than ten different types of mature cells, is based on a single cell type: hematopoietic stem cell (HSC). Within the system, only HSC possess the ability of both multi-potency and self-renewal. Multi-potency is the capacity to differentiate into functional blood cells of all kinds. Self-renewal can generate HSC itself , without differentiation. Since mature blood cells are typically inactive, HSC continuously provide more differentiated progenitors and are able to maintain the HSC capacity throughout their lives by precisely maintaining a balance between self-renewal and differentiation. So, understanding the mechanisms of self-renewal and differentiation of HSC is a major question. In this review, we will focus on the hi-level structure of the hematopoietic process, our current understanding of the molecular and microenvironmental factors that control s...